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Organic Letters

23 February 2024

Mantidisflavin A: A Riboflavin Derivative Featuring a 6/6/6/5/5 Skeleton from the Egg Cases of the Insect Tenodera sinensis Saussure and Its Anti-Renal Fibrosis Activity

Shi-Gang Peng, Xiao-Ning Liu, Madhu Babu Sura, Yong-Ming Yan, Yong-Xian Cheng

10.1021/acs.orglett.3c04035

As the folktale goes, "A mantis catches a cicada, unaware of the yellow bird behind", portraying the law of the jungle. Τhe mantis lays eggs protected by an ootheca to ensure continuity. From the egg pod tonic for kidneys that is also beneficial for reproduction, a riboflavin derivative was discovered, providing new insights into insect-derived natural products.